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Off The Grid
2 days ago
A collection of items and links about the Baltimore Orioles . . . sometimes, baseball in general.


To understand Viagra, you need to understand erectile dysfunction. To start simply, erectile dysfunction is when a male is unable to develop or sustain an erection. This failure to launch is very much a bio-engineer process. At first thought, you might think that the penis is like any of your other appendages. By that, I mean, when you move your arm, you do so by employing muscle contractions. Erections do not work this way. An erection is the result of a hydraulic process that controls blood flow in the penis and, specifically, the corpora cavernosa.
Erectile dysfunction is often caused by too low a concentration of cGMP. This biological process has three easily identifiable parts for us to manipulate:
Now what makes this mechanism work to fix erectile dysfunction is that the corpora cavernosa contains PDE isozyme 5. PDEs have several shapes and each are rather specific to a certain function. This is quite important physiologically and pharmacologically. For instance, biologically it is important that erectile function (PDE 5) is not regulated concurrently with heart contractility (PDE 3). Otherwise, reproduction would have a high rate of lethality. Likewise, for pharmacological use, it allows us to focus on inactivating or inhibiting a specific PDE isozyme. Viagra has a 10,000 times greater affinity to binding with PDE 5 than PDE 3. This is actually why Viagra was originally a failed drug. It was developed to help with hypertension, but the compound had little effect on PDE 3. By accident, they found it worked on erectile dysfunction.
The specificity of Viagra makes it initially out to be an unlikely PED. Studies have shown that this compound can help with pulmonary vasodilation in newborns and patients with severe heart conditions. Furthermore, in 2006 Hsu et al. found that Viagra could improve athletic performance by 40% at 10,000 ft. No dose dependant relationship was observed. Nor was this effect observable at lower altitudes. Experiments at lower elevations were followed up using Cialis (another PDE 5 inhibitor, but certainly different) by Di Luigi et al (2008) and found that under these conditions there were no observable effects. It appears that Viagra's vasodilatory effect works, but only in cases of severe hypoxia. Arguably, baseball players may experience this at Coor's field (5200 ft). I doubt it. If anyone has hiked at 10k, you can tell it is far different from hiking at 5k. With baseball being a game of short-lived moments of exertion, I doubt that the body will ever come under hypoxic conditions. Although I doubt it would work, maybe it would be more useful for cyclists, track and field, basketball players, or football players. Guys who you actually see physically drained after games. Of course, this comes with the caveat of high altitude hypoxia where oxygen diffusion rates are significantly depressed.
Unlike those, the use of Viagra is based in some scientific fact. It is a vasodilator . . . though an incredibly specific vasodilator. It reminds me of Ivan Rodriguez and countless other ball players. They piss on their hands to prevent blistering. This actually makes scientific sense, but it is misapplied. Check your hand moisterizer and you'll find uryl sulfonate or some version of that. That is basically urea. Piss. The lack of understanding exhibited by ball players, but not by chemists, is that urea has to be on your hands for several minutes for it to keep your hands soft. So, if you want to be cheap about it . . . soak your hands in a bucket of urine for 20 minutes and you'll beat the system. hGH is another PED that is similarly rooted in science, but is misapplied. Players took hGH thinking it would help them develop muscle when all it did for them was cause acromegaly. The list goes on and on and on. The key is to remain skeptical when any drug emerges from the gym. Most often, it does not do much of anything but be a drain on your wallet and your liver.
Introducing Kyle Hudson 
Grading Out
over-swinging?) and his weight gets way back in his body. Rather than a perpendicular line from helmet to knee, Hudson is closer to 60-degrees. When coupled with a leading top hand, this could again be an obstacle to consistent hard contact against advanced pitching. Still other times, Hudson reverts more of a "slap" approach, throwing the bat head at the ball rather than attacking with a forceful plane. The Orioles will work to normalize his approach and get him into a more consistent routine from load to contact. This may be as simple as getting Hudson to do the reps in BP -- something that was likely cut into by the demands of his football commitment. Though he's a bit all over the place right now, there are enough "adequate" swings to give hope that a consistent professional hitter is buried in there.
The curves depicted to the right show the effect of age on fielding efficiency (orange) and range (black). Each horizontal mark represents five plays for both axises. The RZR line has been normalized for the average number of chances encountered at 1B for a full 162 game 9 inning season. For instance, if a player moves from one horizontal line to the next over the course of two seasons then the player has improved or declined by five plays. A single play is worth about 0.6 runs, so each line represents 3 runs saved or lost. Three lines roughly represent a win gained or given.
Introducing L.J. Hoes 
offspeed stuff down the road. His hands and upper body are excellent. His hands stay tied to their position relative to his shoulders, keeping a short path to the ball. He has a still head and keeps his front shoulder closed and driving towards the pitch.
Stotle's Notes
Ken Rosenthal reports that the Orioles are listening to any and all offers for these two relievers. The Orioles would love to move two of their veteran relievers, lefty Jamie Walker and righty Chad Bradford. Walker and Bradford are specialists whose inability to work multiple innings forces manager Dave Trembley to overuse younger pitchers such as Jim Johnson and Matt Albers.
"We're on an APB right now, trying to find a shortstop as a front office," MacPhail said. "We've sent the word out to our scouts. We're going to continue to evaluate our internal options and we're going to continue to look outside the organization as well to see if we can find something. We're not really satisfied with the productivity we've gotten out of that position to this point. We've got to keep working to try to make it better."
Lillibridge is suffering mightily in AAA Richmond at the moment. His stock has plummeted, but the Braves are known for somehow figuring out to sell high. He seems like someone who will be kept on unless the Braves think they are getting his true value. With Tex sure to leave this offseason and the Braves within striking distance of first place, they may decide to go all in again this year. The Braves' infield is set for years up the middle, so Lillibridge could be considered excess. Diory Hernandez is in the same boat as Lillibridge, but is putting together a better season. He is a high contact guy with speed, but horrible base running skills. Diory may be more available.
Twins - Sergio Santos
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